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Zappetite
The Ultimate Appetite Suppressant
Zappetite: The Ultimate Appetite Suppressant
Zappetite™ – The Ultimate Appetite Suppressant™ is a unique and
novel formula containing new ingredients designed to eradicate
appetite, burn calories at rest, and increase thermogenesis with
NO stimulant side effects. There is no other formula that contains
the revolutionary combination of ingredients found in Zappetite.
OEA (Oleoylethanolamide) is a cannabinoid receptor agonist that
has been clinically proven to decreases appetite and body weight.
Hoodia Gordonii is a plant found in southern
Africa containing the P57 compound, which is known for its amazing
appetite suppressing activity. Simondslim™ contains Jojoba seed
extract standardized for Simmondsin, which has been demonstrated
to dramatically decrease appetite and body weight. LotuSlim™ an
ingredient exclusive to Zappetite is a standardized extract of
Lotus Leaf, which has been shown to liberate fat stores and
decrease body weight.
Evodiamine is vanilloid receptor agonist that
utilizes the same receptor as the red pepper ingredient capsaicin,
which increases body temperature and caloric expenditure. Angelica
dhaurica is another ingredient exclusive to Zappetite contains the
first standardized extract of imperatorin, which has been shown to
act an oxidative uncoupler, increase fat burning hormones and
decrease fat storing hormones. Sceletium tortuosum is yet another
ingredient exclusive to the Zappetite formula.
Traditionally know as the “feel good herb”
because of its mood enhancing effects sceletium has also been
documented for its use in treating relief of the stomach and tooth
pains but it was used sparingly because of its “side effect” of a
loss of appetite! There is no other formula currently in existence
that possesses the appetite crushing and thermogenic properties of
Zappetite. ZAPP your appetite away RIGHT NOW with Zappetite!!!
For more information on each of the ground
breaking ingredients see below:
Oleoylethanolamide
Oleyoethanolamide is a naturally occuring amide of oleic acid and
ethanolamine,synthesized in the human body primarily by upper part
of the small intestine especially when the meal is rich with fats.
It belongs in a family of naturally occurring fatty acid
ethanolamides(FAEs), present in both animal and plant
organisms[1,2]. It received little attention till it was found
that a member of the same family, anandamide, served as an
endogenous ligand for cannabinoid receptors(3,4) the
G-protein-coupled receptors targeted by Ä9-tetrahydrocannabinol in
marijuana [5, 6].
It was found that in the duodenum and jejunum of rats and mice,
OEA levels change in response to nutrient status- they are lower
in food-deprived than free-feeding animals, and return to normal
values upon refeeding [7]. This changes happen in the upper part
of the small intestine-the part most associated with food intake
and feeding behaviour[8].OEA levels in the rodent small intestine
also display diurnal fluctuations. They are higher during the
daytime, when animals are satiated, and lower during the
night,when they are awake and actively feeding [9]. These findings
led researchers conclude that OEA will affect appetite and feeing
behaviour. Indeed, studies in mice have shown OEA to suppress
appetite in a time and dosage dependent way[10-13]
Apart from it’s appetite suppressing abilities, OEA is also a
potent PPAR-á agonist. PPAR-á receptors are a class of nuclear
receptors that are also the target for antihyperlipidemic drugs
whose stimulation induces increased fatty acid catabolism, lower
blood lipid levels and lowered body weight gain[14,15]. In fact,
OEA is such a powerful PPAR-á agonist that it’s agonistic action
exceeds that of many other PPAR-á agonists[16]. Indeed, apart from
it’s antiorexiant actions, OEA has reduced weight when
administered chronically to both obese and lean mice.[17] All
current data suggests OEA as a very potent compound for the
management of appetite and treatment of obesity[16]
Hoodia Gordonii
Hoodia Gordonii is a cactus-like plant from South Africa, from the
large Milkweed family. Reports and interviews from South Africa
natives suggested that the plant could assuage both the feeling
and “pangs” of hunger that occurred during the long treks.[18]
Animal studies compromised on extracts from various parts of the
plant have shown that Hoodia Gordonii extract can reduce appetite,
balance blood sugar levels and promote weight loss, even in
overfed animals[19], Animal safety studies have not shown any
deleterious side effects independent of the weight loss itself.
The putative active component in these sap extracts is a
trirhabinoside, known as P57AS3. ZAPPED is currently the only
supplement on the market containing Hoodia Gordonii extract that
has been tested positive for P57. The mechanism of action of P57
was studied in rats[19]. It was found that P57 increases ATP
concentration in the hypothalamus(the part of the brain that among
other thing modulates feeding, body temperature, sleep and
hormonal release) by 50-150%. It has been found that following
long time hypo caloric diets, hypothalamic ATP levels drop by
40-60%, which may very well lead to decreased hormonal production,
sleep problems, tiredness e.t.c. Summing up current evidence,
apart from the appetite suppression, P57 is very important from
combating the side effects following caloric-restricted diets.
Unlike other bogus products on the market, ThermoLife Hoodia tests
positive for P57. View our test results (PDF format)
Slimondslim™
The jojoba plant (Simmondsia chinensis) is a shrub cultivated in
arid and semiarid regions for its oil containing nuts. When the
leftovers of oil production (jojoba meal) were supplemented to
animal food, a profound reduction in food intake was observed. It
was demonstrated that simmondsin, a glycoside, was responsible for
the appetite-reducing effects of jojoba meal [20]. No major toxic
effects have been noted after long-term administration of low
doses of simmondsin inducing a sustained food intake and growth
reduction in growing rats [21,22]. The food intake-reducing
activity seems to be at least in a great part mediated via the
vagal nerve since vagotomy significantly reduces the simmondsin-induced
food intake inhibition [23]. Further studies on rats have shown
the anorectic effects to be dose-dependent, improve with continued
simmondsin administration, are greater for overfed rats compared
to underfed rats and can also induce taste aversion to craved
foods like a saccharin solution[24]. Simmondsin is powerful agent
to reduce craving for food.
LotuSlim™
The Lotus Leaf (Nelumbo nucifera)is a traditional herb, primarily
found in India, used for it’s refrigerant, cardiotonic, astringent
and liver protecting actions. Studies have also demonstrated that
it possesses potent antioxidant,[25], anti-hyperlipidemic[26] and
antiviral[27] actions. A study on rats has demonstrated that Lotus
Leaf can lower heightened glucose levels, improve glucose
tolerance, potentiate insulin activity (both endogenous and
exogenous) and reduce glucose absorption [28].
Evodia rutaecarpa
Evodiamine, isolated from the dry unripened fruit of Evodia
rutaecarpa Bentham, is used for it’s analgesic,, antiemetic,
astringent, and antihypertensive effects in traditional Chinese
Herbalism. [29]. Evodiamine also possesses antioxidant and
anti-inflammatory activities[30] as well as antianoxic action on
oxygen-deprived brain cells[31].
The exact mechanisms of action of Evodiamine are many and still
under research. In a study in rats[32], evodiamine demonstrated
potent activity as a Cholecystokinine(CCK) agonist. The functions
of cholecystokinin (CCK) include stimulation of pancreatic enzyme
secretion and inhibition of gastric emptying[33]as well as
suppression of food intake [33]. Thus, evodiamine can extend the
satiating effect of food by slowing food emptying and reduce
overall food intake. Evodiamine also exerts it’s fat loss actions
through stimulation of the vallinoid receptors, in the same way as
capsaicin.[34] In a study performed on rats , Evodiamine would
induce heat loss and heat production at the same time and
dissipate food energy, preventing the accumulation of perivisceral
fat and the body weight increase.[34]
Angelica Dhaurica
Angelica dahurica Bentham et Hooker (Umbelliferae)is a perennial
herb distributed in the whole area of Korea, and its root has been
most frequently prescribed as a sedative and an analgesic in
Chinese medicine[35]. Angelica species have been traditionally
used from the middle ages for various ailments. From various
phytochemical studies, it has now been established that the
majority of Angelica species contain quite high amounts of
biologically active coumarins, predominantly simple- and furano-
coumarins like umbelliprenin [36], bergapten, [37] imperatorin
[38], isoimperatorin [39], byakangelicin [40], etc., and other
active components. Angelica Dhaurica’s furanocumarines imperatorin
,isoimperatorin , and oxypeucedanin are proven to have potent
acetylcholynesterase inhibitory activity. Acetylcholynesterase is
the enzyme that breaks up the neurotransmitter acetylcholine into
acetic acid and choline. Among other things, acetylcholine dilates
and relaxes blood vessels, which allows easier removal of fatty
acids from adipose cells and also increases c-GMP concentration in
fat cells by up to 350% in vitro.[41] Furanocoumarins such as
oxypeucedanin hydrate, bergapten, xanthotoxin, imperatorin and
phellopterin can also activate adrenalin-induced lipolysis.
Imperatorin, oxypeucedanin hydrate and phellopterin also activate
ACTH-induced lipolysis. Byakangelicin, neobyakangelicin and
isopimpinellin strongly inhibite insulin-stimulated lipogenesis.[42]
Sceletium tortuosum
Sceletium Tortuosum Herba (kougoed) is a traditional herb found
mainly in the Western and Eastern Cape provinces, from Namaqualand
to Montagu. Sceletium species have been shown to contain at least
9 indole alkaloids, belonging to one of three structural types. In
S. tortuosum (1-1.5% alkaloids) mesembrine appears to be most
abundant (0.3% and 0.86% have been reported, respectively, in leaf
and stem). Mesembrenone and 4’-O-demethylmesembrenol are also
present. Tortuosamine, also isolated from S. tortuosum, represents
a second structural type in which the pyrrole ring is opened.
Alkaloid levels appear to fluctuate seasonally and may be highest
in late spring/early summer; this is the time when plants are
traditionally gathered and prepared for use
Directions:
As an
adult dietary supplement for weight loss and appetite suppression
take 2 capsules twice daily with 12 ounces of
water preferably in between meals. |
